ABSTRACT
Basic principles 75 Principles of treatment 77 Drug development 79 Classification of cytotoxic drugs, mode of action,
toxicities and clinical utility 81
Drug resistance 90 Novel anti-cancer therapies 97 References 105
Chemotherapy drugs are developed for their potential to cause a greater proportion of cell death among neoplastic as opposed to normal cells. Differences exist between normal and malignant cells that result in the latter being more susceptible to anti-cancer drugs by virtue of their biological and proliferation characteristics.
