ABSTRACT
The Kveim-Siltzbach (K-S) skin test was discovered as a promising diag-
nostic tool for sarcoidosis. Its specificity remains unquestioned if the test antigen used has been properly validated. It takes painstaking efforts to
select and validate a K-S antigen. Usual source of the antigen is more often
the spleen than the lymph nodes, riddled with granulomas of sarcoidosis. It
is not uncommon to find less than half the sarcoidal spleens tested, with
specificity suitable enough to be used as a test material (1).
