This chapter presents a multiscale data analytics approach for modeling the US healthcare system as an enterprise. The US healthcare enterprise encompasses public and private entities with significant government involvement in policies and programs that have widespread interactions and effects at all levels of the system; in other words the US healthcare enterprise is a complex adaptive system. Hybrid models are applied to a selected health service and proposed interventions to affect outcomes and costs. Type 2 diabetes management is used as a case study with selected policy and technology interventions to deal with the lifetime complications and consequences of this condition. The healthcare system is a large and comprehensive example of a service- oriented enterprise. The chapter applies line of sight performance modeling concepts, along with an ESE process, to the formulation of a comprehensive reference health services system framework and associated data and multiscale modeling methods.