ABSTRACT
Since the discovery of the practical applications of the Radon transform by Hounseld in the mid-twentieth century, tomographic imaging has been a driving force in the advancement of medical science and research. X-ray computed tomography (CT) scans have given physicians and engineers a noninvasive and nondestructive tool to acquire high-resolution images of the internal structure of a patient or material sample. Emission tomography scans such as single-photon emission CT (SPECT) and positron emission tomography (PET) have also given us the ability to track chemical tracers within a living organism. Now that nanoparticles are nding a plethora of biomedical applications, an imaging modality able to acquire a tomographic image of nanoparticle distributions in vivo could assist in the development of new therapeutic or diagnostic nanoagents.
