Moisturizers are marketed as products that combat the signs of dry skin by delivering moisture to the skin. They are appreciated by the consumer for making the skin smooth and pliable. Since the discovery of Blank1 that water has a plasticizing effect on the stratum corneum (SC), the main goal of formulators was to develop moisturizers that deliver more moisture. However, enhancement of hydration, softness, and smoothness are short-lived effects, lasting only for hours. Therefore, moisturizers need to be reapplied frequently. In short-term in vivo studies the improvement of skin mechanics or plasticity2 and hydration parameters3 have been analyzed following a single application of a moisturizer.