This chapter explores the assessment of the irritant potential of cosmetic ingredients and products and details a number of methodologies available, chiefly in human volunteers. The practicalities associated with conducting studies using human volunteers are also examined. To try to increase

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the practical utility of the material, rather than present a generic review, focus is on the general strategy and methods employed in our own laboratory. It should be made clear at the beginning that all assessments should be made on a case by case basis; the methods are not to be slavishly applied to the safety assessment of all new moisturizers.