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      Chapter

      PET and SPECT as Platforms for Molecular Imaging
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      Chapter

      PET and SPECT as Platforms for Molecular Imaging

      DOI link for PET and SPECT as Platforms for Molecular Imaging

      PET and SPECT as Platforms for Molecular Imaging book

      PET and SPECT as Platforms for Molecular Imaging

      DOI link for PET and SPECT as Platforms for Molecular Imaging

      PET and SPECT as Platforms for Molecular Imaging book

      ByBuck E. Rogers
      BookMolecular Imaging of the Lungs

      Click here to navigate to parent product.

      Edition 1st Edition
      First Published 2005
      Imprint CRC Press
      Pages 36
      eBook ISBN 9780429115431
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      ABSTRACT

      I. Introduction 60

      II. SPECT Imaging 60

      A. Principles of SPECT Imaging 60

      B. Radionuclides Used in SPECT Imaging 62

      III. PET Imaging 64

      A. Principles of PET Imaging 64

      B. Radionuclides Used in PET Imaging 66

      IV. SPECT Imaging vs. PET Imaging 67

      V. Applications of PET and SPECT Molecular Imaging 69

      A. Imaging of RNA 69

      B. Imaging of Endogenous Proteins and

      Protein Function 71

      Imaging of Intracellular Proteins 71

      Imaging of Transmembrane Proteins 72

      C. Imaging of Exogenous Marker Genes 76

      Herpes Simplex Virus-1 Thymidine Kinase 77

      Sodium Iodide Symporter 78

      Somatostatin Receptor Subtype 2 79

      Dopamine-2 Receptor 80

      VI. Summary 80

      Acknowledgments 80

      References 81

      I. Introduction

      With the development of new molecular imaging probes, sophisticated animal

      models, and small-animal imaging devices as well as advances in molecular

      biology techniques, molecular imaging has become increasingly important for

      understanding basic biological processes in living subjects. Molecular imaging

      can be defined as the characterization of biological processes at the cellular

      and molecular levels in living animals or humans using remote imaging detectors

      (1). This can differ from “classical” diagnostic imaging that focuses on imaging

      the end result of these biological processes (2). Molecular imaging modalities

      include nuclear imaging, optical imaging, magnetic resonance imaging (MRI),

      computed tomography (CT), and ultrasound. All of these modalities offer differ-

      ent advantages and limitations for molecular imaging. Most of these advanta-

      ges and limitations are centered on issues of spatial and temporal resolution,

      sensitivity, molecular probe availability, image acquisition and analysis time,

      and cost. The focus of this chapter will be on nuclear imaging, in particular

      single photon emission computed tomography (SPECT) and positron emission

      tomography (PET). These techniques have the advantages of having a high

      sensitivity, being extremely quantitative, and having a number of probes

      readily available. They are, however, relatively expensive, expose the subject

      to radiation, and have lower spatial resolution than some of the other imaging

      modalities. This chapter will describe the basics of SPECT and PET imaging,

      describe the advantages and disadvantages of each modality, and give examples

      of how each platform is used for molecular imaging applications.

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