ABSTRACT
Dosing of antibiotics in organ dysfunction can be problematic. One must weigh the risks of overdose, which can range from nausea to seizures, against the risk of underdose, which can lead to resistance and treatment failure. Additionally, the level of organ dysfunction of the kidneys and/or the liver and the status of the patient are also critical factors. When a patient is receiving hemodialysis (HD), peritoneal dialysis (PD), or continuous renal replacement therapy (CRRT), clearance of the drug changes and dosing must be adjusted for each of these modalities. This chapter will elucidate some of the dosing and administration issues of antimicrobials in patients with renal or hepatic failure and those undergoing the different types of renal replacement therapy.
ANTIBIOTIC DOSING IN HEPATIC FAILURE
