ABSTRACT
Metabolomics represents a global understanding of the metabolite complement of integrated living systems and dynamic responses to the changes in both exogenous and endogenous factors [1]. In modern metabolomics, a hierarchy of “omics” terms is dividing research into areas that can be studied separately and as interacting phenomena [1-4]. From many varied denitions of metabolomics, the most generalized is the one that denes metabolomics as the systematic study of unique chemical ngerprints that specic cellular processes leave behind [5]. It is generally accepted that as an addition to the family of omics, metabolomics appeared as an integrative representation of the interactions of the genome, transcriptome, and proteome with the environment [5,6]. The combination of these four omics provides a platform to investigate the regulation of the cellular environment from the specic codes stored in the DNA through its expression by proteins (e.g., enzymes and structural proteins) to the chemical conversion of small molecules within biochemical pathways [5,6].
