ABSTRACT

The term proteome refers to the totality of the proteins in a cell, tissue, or organism. Proteomics is the study of these proteins-their identity, their biochemical properties and functional roles, and how their quantities, modications, and structures change during development and in response to internal and external stimuli. The eld of proteomics has been propelled by advances in mass spectrometry (MS) and other techniques that have made it possible to analyze proteins in large numbers of biological samples rapidly and at low cost.