ABSTRACT
Nail disorders are rarely subjected to thorough histopathological investigation. In contrast to skin, the nail is not easy to biopsy and many physicians as well as patients are therefore reluctant to undertake this procedure. To obtain relevant results it is necessary to consider the following:
1 Nail changes usually reflect a pathological process of the matrix or (much less frequenly) of the nail bed. The biopsy must contain a relevant piece of matrix.
