ABSTRACT
INTRODUCTION This chapter provides the reader with a basic understanding of the role of neuropsychology in the evaluation of cognition and behavior in Parkinson’s disease (PD), with an emphasis on patterns of neurobehavioral functioning, measures used to assess these functions, and evidence-based research supporting potential underlying mechanisms. In this context, current fi ndings regarding the emerging and controversial concept of “mild cognitive impairment” in PD are presented. Challenges and limitations encountered in test administration and interpretation of results are also enumerated. The pathophysiology of PD is described briefl y in order to provide a framework for understanding the hypothesized neurobehavioral processes and heterogeneity in cognitive profi les. Treatment options and associated side effects relevant to neuropsychological and psychiatric status are discussed. Finally, similarities and differences in Parkinson-plus syndromes and the utility of neuropsychological assessment in differential diagnoses are presented.
