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      Chapter

      Deep brain stimulation
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      Chapter

      Deep brain stimulation

      DOI link for Deep brain stimulation

      Deep brain stimulation book

      Deep brain stimulation

      DOI link for Deep brain stimulation

      Deep brain stimulation book

      ByKelly E. Lyons, Jules M. Nazzaro, Rajesh Pahwa
      BookHandbook of Parkinson's Disease

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      Edition 5th Edition
      First Published 2013
      Imprint CRC Press
      Pages 18
      eBook ISBN 9780429066474
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      ABSTRACT

      Stereotactic surgeries for movement disorders were introduced in the late 1940s (1-3) but were not widely accepted due to signifi cant morbidity, mortality, and limited knowledge of the appropriate target for symptomatic benefi t. With advancements in pharmacological therapy, particularly the availability of levodopa, these surgeries were rarely performed for Parkinson’s disease (PD) until the late 1980s (4). Based on the limitations of drug treatments for PD, and a better understanding of the physiology and circuitry of the basal ganglia there has been a marked increase in surgical therapies for PD. In addition, advances in surgical techniques, neuroimaging and improved electrophysiological recordings allow stereotactic procedures to be done more accurately leading to reduced morbidity. Deep brain stimulation (DBS) has largely replaced ablative surgery as the preferred surgical treatment for PD. There are currently three potential brain targets for the treatment of PD: the ventral intermediate (Vim) nucleus of the thalamus, the globus pallidus interna (GPi), and the subthalamic nucleus (STN).

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