ABSTRACT
diseases. The absence of eosinophiluria does not exclude the diagnosis. Proteinuria is generally mild (<1 g/1.73 m2 per 24 hours). The predictive value of gallium scanning is limited. Diagnosis sometimes requires renal biopsy. Therapy is primarily supportive. The likely inciting factor or factors need to be identified and eliminated. Treatment with prednisone (60 mg every other day) for 2 to 4 weeks may hasten the recovery of renal function and may be of benefit in patients who do not regain renal function within 1 week after discontinuing use of the offending agent. Corticosteroids are not indicated in infection-related AIN. Historically, drug-induced AIN has been considered a reversible process, with renal function returning to baseline values in the majority of patients. However, recent studies have shown that impaired renal function can persist long-term in up to 40% of the patients.
