ABSTRACT
K. Valencia,1 E. Bandres2,* and J. Garcia-Foncillas3
1Oncology Division, Center for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain. Email: kvalencia@alumni.unav.es 2Immunology Unit, Hematology Service, Complejo Hospitalario de Navarra, Pamplona, Spain. Email: ebandres@hotmail.es 3Department of Oncology, University Hospital “Fundacion Jimenez Diaz”, Autonomous University of Madrid, Madrid, Spain. Email: jgfoncillas@fjd.es *Corresponding author
miRNAs represent an abundant class of small ncRNAs involved in regulating many cellular processes, including proliferation, differentiation, apoptosis and development. They regulate gene expression by targeting messenger RNAs (mRNA) through sequence-specifi c base pairing with the 3’-untranslated regions (3’-UTR) of mRNAs, resulting in RNA degradation and/or translational repression (Ambros 2004). In the latest version of the Sanger Institute miRBase (version 18) (https://microrna.sanger.ac.uk/ sequences/index.shtml), to date, 1527 human mature miRNAs sequences have been deposited.
