ABSTRACT
Current evidence documents that the risk of developing colorectal cancer by age 70 in HNPCC/Lynch Syndrome patients is approximately 45% in men and 35% in women (Palomaki et al. 2009). The estimated risk of developing endometrial cancer among women with HNPCC/Lynch Syndrome may be as high as 60-65% by age 70 (Lu et al. 2005; Hampel et al. 2008). To date, a larger number of population-based studies have focused on newly diagnosed colorectal cancer populations. However, since endometrial cancer may be the sentinel cancer in HNPCC/Lynch Syndrome women, this subgroup of patients represents an additional cohort for populationbased screening. In a future era of cost containment, the cost effectiveness of such population-based screening will be carefully scrutinized and balanced against the health benefi ts and cancer incidence reductions to these high risk HNPCC/Lynch Syndrome groups.
