ABSTRACT
CONTENTS 11.1 Introduction 283 11.2ScaŽold Design for Ligament-to-Bone Interface Tissue Engineering284 11.3ScaŽold Design for Tendon-to-Bone Interface Tissue Engineering287 11.4Summary and Future Directions290 References291
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from the tissues they connect. Furthermore, the transition between various tissue types is characterized by a high level of heterogeneous structural organization. In light of this complexity, functional tissue engineering involves utilizing cells, growth factors, and biomaterial scaŽolds in a variety of ways to engineer tissues in vitro and in vivo. …is chapter focuses on complex scaŽold design currently used to regenerate so§ tissue-to-bone interfaces, in particular the ligament-to-bone and tendon-to-bone interface. Each section will begin with a brief description of the current understanding of the requirements for biomimetic and functional interface scaŽold design, which have been distilled through characterization of the structure-function understandings of the native interface. …is is followed by a brief review of scaŽold design currently researched for so§ tissue-to-bone interface tissue engineering. Lastly, potential challenges and future directions in this rapidly expanding area of functional tissue engineering will be discussed.
