ABSTRACT

Strategies, and the Future 2 1.1.1Heart2 1.1.2 Lungs 5 1.1.3Liver6 1.1.4Kidney 6 1.1.5Pancreas7 1.1.6Intestinal Tissue8 1.1.7Spleen and Lymph Nodes 9 1.1.8Eyes 9

1.1.8.1Retina 9 1.1.8.2Cornea 10 1.1.8.3Lens 10

1.1.9Musculoskeletal Tissues10 1.1.9.1Bone and Ligament10 1.1.9.2Cartilage11 1.1.9.3 Meniscus 13 1.1.9.4Rotator CuŽ 13

1.1.10Neural Tissue 14 1.1.10.1 Spinal Cord Injuries 14 1.1.10.2Parkinson’s Disease15

1.1.11Vascularized Tissue Constructs 15 1.2 Regenerative Engineering: Future Challenges 16 References16

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Regenerative engineering is an interdisciplinary ‡eld that merges bioengineering, material science, and life science for the development of biological substitutes that will replace, restore, and/or regenerate tissue function. It combines cells, growth factors, and a synthetic scaŽold to form a construct that will be functionally, structurally, and mechanically equivalent to or greater than that of the native tissue that has been damaged or lost. Great strides have been made in this area to meet the growing needs for regenerative strategies, but while there have been great accomplishments thus far, the ‡eld continues to rapidly evolve. Here in this chapter, we describe the trends and research in the areas of regenerative engineering, tissue engineering, and regenerative medicine.