ABSTRACT
Vacuolar-type H+-ATPase (V-ATPase), cytohesins, and Arf-family GTP-binding proteins (Arfs) are essential for vesicular trafficking of
receptors and their signaling along endocytic pathway of eukaryotic
cells. Deficient function of V-ATPase, cytohesins, and Arfs in
endocytic trafficking and signaling of receptors have been recently
recognized as important mechanisms in a variety of human diseases
including diabetes and its complications. In the past few years,
significant progress has beenmade in our understanding of function
and regulation of V-ATPase and their cell biological role in crosstalk
with cytohesins and Arfs. Here, we review these studies on novel
roles of V-ATPase, cytohesins, and Arfs in the regulation of vesicular
trafficking and signaling events within endocytic pathway. We also
discuss novel role of aldolase in regulation of cross-talk between V-
ATPase and cytohesins/Arfs. Finally, we give special emphasis on the
potential role of these proteins in diabetic complication of kidney
proximal tubule function and their use as emerging therapeutic
targets.
