ABSTRACT
Oral squamous cell carcinoma (OSCC) is the most common malig-
nancy of the oral cavity. Accounting for between 90% and 95% of
all malignant lesions of the mouth, OSCC has become practically
synonymous with oral cancer [1, 2]. The main characteristics of
OSCC, a solid tumor, are acidity and hypoxia, both ofwhich have been
implicated in tumor metastasis [3], sensitivity to chemotherapy
agents [4, 5], and proliferation [6].