ABSTRACT
The complex biology of solid tumor development represents amajor
obstacle to its successful treatment. In addition to cancer cells,
this is in part due to the fact that solid tumors are heterogeneous,
comprises various cells, including stromal, inflammatory, and
vascular cells. Although the regulation of intracellular pH has been
shown to be critical for many cellular functions, pH regulation has
not been fully investigated in the field of cancer. It has been shown
however, that cellular pH is crucial for important biological functions
including cell proliferation, invasion andmetastasis, drug resistance,
and apoptosis. Thus, pathways affected by pH signaling are often
dysregulated in cancer.
