ABSTRACT
Spectrophotometric intracutaneous analysis (SIA)scopy is a skin-imaging technique that allows the rapid, noninvasive in vivo quantification and assessment of (eu) melanin, (oxy) hemoglobin, and dermal collagen within human skin. A powerful feature of SIAscopy is that it produces independent linear measurements of each of these endpoints, which can also be mapped over the skin, producing images called SIAscans. SIAscopy was originally developed for the assessment of malignant melanoma (1) where the accurate assessment of melanin, blood, and collagen has been shown to increase diagnostic accuracy (2) for the disease.
