ABSTRACT

Acknowledgments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 376

References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 376

of US with the functional information that can be provided by optical techniques. e main dierence between USMOT and photoacoustic tomography (PAT; described in Chapter 12) is that in PAT, light is used to generate sound within the tissue via the absorption of light (usually by blood). e sound waves are then detected and are used to form an image. In USMOT, light illuminates the tissue and US (delivered via an US transducer) is used to modulate the light within the tissue. e modulated optical signal is then detected and is used to form an image. It can be used to image absorption, scattering, or uorescence within tissue or 3D cell cultures.