ABSTRACT
Recent evolutions in radiotherapy technology and the development of intensity-modulated radiation therapy (IMRT) planning and delivery systems have led to the emergence of image-guided and adaptive radiotherapy (IGART) to meet the new requirements of precise localization and definition of targets and surrounding critical structures at the time of planning and during the course of fractionated treatment (Bortfeld et al. 2006). Although these technological advances have created new opportunities in radiotherapy treatment planning and delivery, it has been noted that robust and computationally efficient software algorithms are still lagging to achieve the optimal utilization of these recent hardware developments (Xing et al. 2007).
