ABSTRACT
The uptake, distribution, and metabolism of organophosphates have been modeled using physiologically based pharmacokinetic (PBPK) approaches (Gearhart et al., 1994; Gentry et al., 2002; Timchalk et al., 2002). However, we have not seen the simultaneous modeling of the agent and its antidotes with all of the mechanisms involved nor has there been any exploring of possible undesired effects because of unintended consequences of mechanistic feedback inuences within the complex physiological system. This work presents such a model and explores various exposure scenarios along with various dosing regimens of atropine and oximes postexposure combinations.
