ABSTRACT
Introduction Epilepsy is a medical condition that is very frequent around the world. It is estimated that 1% of the population suers from epilepsy. From these patients, only 70% are controlled with antiepileptic medication. Other 30% of patients may benet from surgical intervention. All antiepileptic drugs were withdrawn to avoid any possible interference with the neuromodulation procedure and were replaced with phenytoin. Anti-epileptic drugs were tapered and daily-depth recording was performed for epileptic. Most evident and fastest antiepileptic responses were found in ve patients in whom the stimulation contacts were located either at the ante rior pes-hippocampus near the amygdala or at the anterior parahippocampal gyrus near the entorhinal cortex. To evaluate the antiepilepticeects of subacute hippocampal stimulation on temporal lobe epileptogenesis, the number and type of clinical seizures per day and the number of interictal negative electroencephalogram spikes at the epileptic focus per 10 s were evaluated.
