ABSTRACT

Attempts of small countries and terrorist groups to obtain biological

warfare agents have escalated the need to provide the armed forces

and civilians with miniature, easy-to-use, disposable instruments

for detection and identification of potentially hazardous biological

agents. Traditional methods for the detection and identification of

pathogens lack the speed and sensitivity to be of use in the field,

since they are not real time or even typically completed in a single

day. Oneway of dealingwith this problem is to improve the biorecep-

tor that binds the analyte, which is one of the essential elements of

any immuno-based detector device.1 Molecular recognition systems

that can be used for rapid identification can improve response time

and thus avert or reduce the number of casualties associated with

a potential bioterrorism or biowarfare event.2 One of the newer

techniques being developed for construction of bioreceptors for

pathogen detection involves phage display technology.