ABSTRACT
The intense use of muscles during high-intensity exercise or during repeated muscle contractions leads to a decrease in muscle performance and appearance of peripheral muscle fatigue (Allen, Lamb, and Westerblad 2008; Westerblad, Bruton, and Katz 2010). Muscle fatigue is a complex phenomenon with many theories and scientific evidence to explain its process of appearance. Among the scientific evidence, we highlight the depletion of energy sources such as phosphocreatine, glycogen, increased amounts of phosphate inorganic (Pi), adenosine diphosphate (ADP), Ca2+, Mg2+, H+, and lactate, and decreased sensitivity of myofibrils to Ca2+ and higher production or accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) during exercises (Allen, Lamb, and Westerblad 2008; Westerblad and Allen 2011; Westerblad, Bruton, and Katz 2010).
