ABSTRACT
In past decades, there have been remarkable achievements with nanotechnology in the research and development elds of chemical engineering,1 biotechnology,2 and medicinal sciences.3 A size ranging from 1 to 1000 nm has frequently been used in both the nanotechnology science and pharmaceutical science because of its important meaning in biopharmaceutical aspects.4-7
The European Science Foundation (ESF) dened nanomedicines as “the science and technology of diagnosing, treating, and preventing disease and traumatic injury, of relieving pain, and of preserving and improving human health, using molecular tools and molecular knowledge of the human body.”8 With this comprehensive denition, ve main categories of nanomedicines had been established by ESF as “analytical tools”; “nanoimaging”; “nanomaterials and nanodevices”; “novel therapeutics and drug delivery systems”; and
CONTENTS
7.1 Introduction: Nanomedicines and Their Delivery Systems ........................................ 321 7.2 Administration Routes of Nanomedicines .................................................................... 322
7.2.1 Injectible Administration ...................................................................................... 322 7.2.2 Oral Administration .............................................................................................. 322 7.2.3 Pulmonary Administration .................................................................................. 323 7.2.4 Transdermal and Dermal Administration ......................................................... 323 7.2.5 Ocular Administration ......................................................................................... 324
7.3 Nanomedicine Delivery Systems .................................................................................... 329 7.3.1 Biomaterials for the Nanomedicine Delivery Systems ..................................... 329
7.3.1.1 Polymers ................................................................................................... 329 7.3.1.2 Lipids ........................................................................................................330
