ABSTRACT

Diseases ................................................................................................................................. 10 1.6 Current Approach to Diagnosis of Infections ................................................................. 11 1.7 Infectious Diseases: Nanobiosensing Interface ............................................................... 12

1.7.1 Photonic Biosensing: Semiconductors .................................................................. 14 1.7.2 Quantum Dot Semiconductors and Infectious Diseases Biosensing ............... 15

1.7.2.1 Quantum Dots and Virus Detection ...................................................... 17 1.7.2.2 Quantum Dot Biosensing and Human Immunodeciency Virus..... 17 1.7.2.3 Quantum Dot Biosensing and Respiratory Syncytial Virus .............. 18 1.7.2.4 Quantum Dot Biosensing and Inuenza Virus .................................... 19 1.7.2.5 Quantum Dot Biosensing and Hepatitis Viruses ................................. 20 1.7.2.6 Quantum Dot Biosensing and Other Viruses ....................................... 20

1.7.3 Quantum Dots, Bacteria, and Bacterial Toxin Detection ................................... 21 1.7.3.1 Quantum Dot Biosensing and Bacteria: General Principles ............... 21 1.7.3.2 Quantum Dot Biosensing and Biolms .................................................23 1.7.3.3 Quantum Dot Biosensing and Food-Borne Bacteria ........................... 24 1.7.3.4 Quantum Dot Biosensing and Syphilis .................................................25 1.7.3.5 Quantum Dot Biosensing and Mycobacteria ........................................25 1.7.3.6 Quantum Dot Biosensing and Bacterial Toxins ................................... 26

1.7.4 Quantum Dot Biosensing and Fungi .................................................................... 27 1.7.5 Quantum Dot Biosensing and Parasites ...............................................................28 1.7.6 Quantum Dot Biosensing: Conclusions ............................................................... 29

1.8 Plasmonic Nanobiosensing: Emphasis on Infectious Diseases ....................................30 1.8.1 Plasmonics: Basic Principles ...................................................................................30 1.8.2 Surface Plasmon Resonance Biosensing Scheme 1: Detection of Light

Scattering .................................................................................................................. 31 1.8.3 Surface Plasmon Resonance Biosensing Scheme 2: Colorimetric Detection ... 32 1.8.4 Surface Plasmon Resonance Biosensing Scheme 3: Surface Plasmon

Wave-Based Detection.............................................................................................34 1.8.5 Surface Plasmon Resonance Biosensing Scheme 4: Surface-Enhanced

Raman Scattering-Based Detection .......................................................................36 1.8.6 Plasmonic Nanobiosensing: Conclusions ............................................................. 37

It has long been an axiom of mine that the little things are innitely the most important.