ABSTRACT
Mechanotransduction involves the conversion of mechanical stimuli
into a biochemical signal. This mechanism exists at the cellular
level in all living organisms and is observable at the tissue, organ,
and organism level. A well-known example of this hierarchical
response to mechanical forces is the adaptive nature of bone [1,
2]. Observable at the tissue level, an applied mechanical stimulus,
varied above or below the local homeostatic stimuli [3], alters
the rate of bone remodeling, leading to either bone formation or
resorption, respectively [4]. Thus, the skeleton responds to limited
physical stimuli by a reduction in bone density and conversely to
increased physical stimuli by an increase in bone density.
