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Comparative Proteomic Analysis of Streptococcus suis Biofi lms and Planktonic Cells That Identifi ed Biofi lm Infection-Related Immunogenic Proteins
DOI link for Comparative Proteomic Analysis of Streptococcus suis Biofi lms and Planktonic Cells That Identifi ed Biofi lm Infection-Related Immunogenic Proteins
Comparative Proteomic Analysis of Streptococcus suis Biofi lms and Planktonic Cells That Identifi ed Biofi lm Infection-Related Immunogenic Proteins book
Comparative Proteomic Analysis of Streptococcus suis Biofi lms and Planktonic Cells That Identifi ed Biofi lm Infection-Related Immunogenic Proteins
DOI link for Comparative Proteomic Analysis of Streptococcus suis Biofi lms and Planktonic Cells That Identifi ed Biofi lm Infection-Related Immunogenic Proteins
Comparative Proteomic Analysis of Streptococcus suis Biofi lms and Planktonic Cells That Identifi ed Biofi lm Infection-Related Immunogenic Proteins book
ABSTRACT
YANG WANG, LI YI, ZONGFU WU, JING SHAO, GUANGJIN LIU, HONGJIE FAN, WEI ZHANG, and CHENGPING LU
4.1 INTRODUCTION
Streptococcus suis (SS) is a major worldwide pathogen and colonizes the respiratory tract of pigs, particularly the tonsils and nasal cavities [1]. SS is believed to be a normal inhabitant of several ruminants [2]. SS binds to the extracellular matrix (ECM) proteins, including fibronectin and collagen [3], of endothelial and epithelial cells [4], [5]. Some studies have demonstrated that SS has the ability to form biofilms [6], [7]. The biofilm mode of growth affords SS several advantages over its planktonic counterparts, including the capability of ECM to trap nutrients and protect against both antimicrobial agents and the host immune responses [6], [7]. Our previous
studies indicate that SS maybe achieve persistent infections in vivo by forming biofilms [8] and hence SS infections might be difficult to treat. Biofilms play a key role in the pathogenesis and persistence of several bacterial infections [9]. It has been postulated that an altered metabolism and changes in gene expressions and protein amounts in biofilms may be responsible for drug resistance, cell adherence and virulence. Recent results indicate that biofilm cells have an active, although altered cell metabolism [10], [11]. Considerable investigation is required to gain a better understanding of biofilm formation.