ABSTRACT
Cancer stem cells have been defi ned, by analogy to normal stem cells, in that they are capable of self-renewal and can generate all the differentiated cells found within the tumor (Clarke et al., 2006a; Singh et al., 2004). Practically, CSCs are characterized by their ability to generate tumors identical to those from which they arise in immuno-compromised mice. Moreover, in order to identify the capacity for self-renewal, xenotransplanted tumors shall have the capacity for serial transplantation in
Color image of this figure appears in the color plate section at the end of the book.
