ABSTRACT
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, pervasive in the aging population. While age-related AD forms are generally sporadic, early onset forms of the disease, which are less frequent, are genetically linked and triggered by autosomal dominant mutations. These mutations, which cause the familial forms of AD (FAD), are allocated to three different genes, the amyloid precursor protein (APP) gene, and the presenilin 1 and 2 (PS1 and PS2) genes.
