ABSTRACT

Sclerosis Sayonara Rangel Oliveira,1,a Ana Paula Kallaur,1,b

Multiple sclerosis (MS) is a complex immune-mediated disease of the central nervous system (CNS), with several pathophysiological processes involved, such as infl ammation, demyelination, axonal damage, repair mechanisms, oxidative stress and excitotoxity, that are involved in this disorder, although these processes are not uniformly present in all patients (Miller et al. 2011). It affects more than two million people worldwide and is a major cause of disability in the young adult population (Javed and Reder 2006).