ABSTRACT
ABSTRACT: To explore the value of combined detection of tumor markers both in nipple discharge and serum in the diagnosis of breast cancer. The serum and nipple discharge from 179 patients including 43 cases of breast cancer and 136 cases of benign tumour was collected and tumor markers of CA153, TSGF, CA125 and CEA were detected. The nipple discharge and serum levels of the four biomarkers in bresat cancer patients were significantly higher than those in benign lesions (P< 0.01), and had a positive correlation with Ki-67, gread, lymph node metastas and tumor recurrence (P< 0.05), and negative correlation with ER and PR (P< 0.05). The sensitivity of the four markes in combination was 97.7% and specificity was 99.0%. The dynamic combined detection of the four biomarkers both in nipple discharge and serum are helpful to the stratification of preoperative patients and benefit to monitoring their recurrence, metastasis and clinical staging of tumors in clinic.
