DOI link for Eosinophilic Gastroenteritis
Eosinophilic Gastroenteritis book
Eosinophilic gastroenteritis (EGE) is an inflammatory condition of the stomach and small intestine, in which eosinophils are the predominant cell type, that may affect all layers of the gastrointestinal tract wall. At endoscopy, EGE findings may include prominent antral lymphonodularity, ulceration, a mass-like appearance, patchy erythema, or may be normal. In contrast to eosinophilic esophagitis (EoE), peripheral eosinophilia or an elevated immunoglobulin (Ig) E level frequently occur with EGE. Clinical experience suggests that either allergy test directed or empiric food antigen elimination is less effective for EGE as compared to EoE. A colonoscopy with biopsies and terminal ileal intubation should be considered in all patients with significant EGE. Many patients are recognized to have both an IgE and non-IgE-mediated inflammatory response with similar cytokines, such as interleukin-5, playing an important role. The long-term outcomes for EGE remain poorly characterized and are dependent on the underlying etiology.