ABSTRACT
BRUCE P. EKHOLM and TERRANCE L. FOX 3M/Riker, 3M Health Care, St. Paul, Minnesota
JAMES A. BOLOGNESE Merck Sharp & Dohme Research Laboratories, Rahway, New Jersey
A physician prescribing a drug for a particular patient must know how much the patient should take, how often, and for how long. Regulatory agencies properly insist that pharmaceutical companies study exhaustively the efficacy and safety aspects of various dosing regimens. The company must answer these questions, among others:
1. What type of response (safety and efficacy) can be expected as a function of dose? .
