Carnitine metabolism and nutrition in peripheral arterial disease

Peripheral arterial disease Peripheral arterial disease (PAD)—a clinical manifestation of underlying aortoiliac and leg atherosclerosis-is characterized by different degrees of arterial stenosis or obstruc tion, with progressive reduction in distal perfusion pressure and blood flow. Clinically, patients with PAD can present without symptoms (asyPAD), with intermittent claudication (IC) until critical leg ischemia (CLI), or with persistent resting pain with or without ischemic skin lesions (necrosis and gangrene).