ABSTRACT
Driven by the benets of human genome sequencing to medical science, many research projects have been carried out to achieve the low-cost and highthroughput sequencing. When the sequencing of human genome is aordable in medical treatments, it will result in signicant improvements in human healthcare, such as fast and accurate diagnostics or personalized medicine. To promote the research, NIH has launched the $1000 genome project. e goal is
11.1 Introduction 311 11.1.1 Sanger’s Method 312 11.1.2 Next-Generation Sequencing Method 312
11.1.2.1 Protein Pores 313 11.1.2.2 Solid-State Nanopores 314
11.2 Simulating the Nanopore-Based DNA Sequencing 316 11.2.1 Simulation Methods 316 11.2.2 Electrohydrodynamics of DNA Translocation through
a Nanopore 318 11.2.3 DNA Transiting a Nanopore: High roughput but Not
Too Fast 319 11.2.4 Sequencing DNA via Transversal Tunneling Currents 322
11.3 Outlook of the Nanopore-Based DNA Sequencing: From the Point of View of Simulation 324
Acknowledgments 325 References 325
to develop a novel sequencing method whose cost for an entire human genome is less than $1000. e XPRIZE foundation also announced $10,000,000 award to the winning team that can sequence the whole genome of 100 subjects within 1 month for $10,000 or less per genome.
