ABSTRACT
Nonimmunologic contact urticaria (NICoU) and other nonimmunologic immediate contact reactions (NIICRs) of the skin comprise a group of inflammatory reactions that appear within minutes to an hour after contact with the eliciting substance and usually disappear within a few hours. These reactions can also be called immediate-type irritancy. NIICRs occur without previous sensitization in most exposed individuals, and they are the most common type of immediate contact reaction.[1]
