ABSTRACT
ABSTRACT Vulvar carcinoma represents 5% of all female genital cancers (1-2 in 100,000 person/year). Squamous cell carcinoma is the most common histological type of vulvar cancer and represents 80%–90% of the cases. Nowadays, there is a big concern about the postoperative sequela and mutilation associated with radical surgery, which is the most common treatment for this disease. Due to this, there are high expectations in new tumor
CONTENTS
18.1 Introduction ........................................................................................................................ 462 18.1.1 Epidemiology ......................................................................................................... 462 18.1.2 Types of Vulvar Cancer ......................................................................................... 462 18.1.3 Vulvar Squamous Carcinoma .............................................................................. 462
18.1.3.1 Vulvar Intraepithelial Neoplasm ..........................................................464 18.1.3.2 Lichen Sclerosus and Hyperplasia .......................................................465 18.1.3.3 Paget’s Disease of the Vulva ..................................................................466
18.2 Noninvasive Markers ........................................................................................................466 18.2.1 HPV ..........................................................................................................................466 18.2.2 Cell Cycle................................................................................................................. 467
