ABSTRACT
Much can be learned from the structural and functional properties shared by the six members of the transient receptor potential vanilloid (TRPV) family of ion channels. In addition, the specializations of each for their physiological roles shed light on the workings of the entire family. is chapter will focus on gating of TRPV1-6 channels, with discussion of permeation, expression patterns, and physiological roles covered elsewhere.1-5
28.1 STRUCTURE OF TRPV CHANNELS TRPV channels are members of the voltage-gated superfamily of ion channels with six-membrane-spanning domains, intracellular N-and C-termini, a (weak) voltage sensor domain in S1-S4, and a pore domain formed by S5-P-S6. Each functional TRPV channel is composed of four identical subunits.
