ABSTRACT
The innate immune response involves a sequence of highly coordinated events that allow leukocytes to exit the bloodstream and travel to the site of infection in a nearby tissue. Polymorphonuclear neutrophils are the fi rst responders in the army of leukocytes, arriving to the infected tissue within minutes of acute trauma. Once there, they carry out their innate function of combating infectious material, through either phagocytosis or release of granular material. Neutrophils are therefore key components in successful clearance of foreign organisms from the body, but the path to reach their fi nal destination is not without obstacles.
