ABSTRACT

High-Throughput Phenotyping of Genetically Engineered Mice (GEM) ............................................. 378 High-Throughput GEM Phenotyping Projects: Primary Considerations .............................................. 379

Why High-Throughput Assessments of GEM Are Necessary .......................................................... 379 Approaches to High-Throughput GEM Phenotyping ....................................................................... 380

Methods of Mutagenesis for High-Throughput GEM Phenotyping Projects .............................. 380 Phenotyping Postnatal Mouse Mutants in High-Throughput GEM Phenotyping Projects: The EMPReSS Pipeline ........................................................................... 380 Phenotyping Embryonic Lethal Mouse Mutants in High-Throughput GEM Phenotyping Projects: The CMHD EMPReSSslim Pipeline .............................................................................381