ABSTRACT
Medicine continues to evolve, and the important changes that are currently promoted are the result of what is called evidence-based medicine. Evidence-based medicine is based on a consensus decision based on the best available science to guide clinical care. For lung cancer computeraided detection (CADe) and computer-aided diagnosis (CADx), there has been no such consensus decision. For CADe for lung cancer, there is evidence obtained from welldesigned cohort or case control studies; these are all almost based on retrospectively assembled cases, but with reinterpretations by radiologists using the CADe programs. e studies are sucient, but not optimal to indicate full acceptance for clinical use. e level of risk from routine clinical implementation is not yet established.
