ABSTRACT
ABSTRACT Bone remodeling denotes the continual renewal of the bone matrix over our lifetime. This renewal is operated by self-contained groups of bone-resorbing cells called osteoclasts and bone-forming cells called osteoblasts. These functional groups of cells ensure the tight coordination between bone resorption and bone formation required for skeletal maintenance and mineral homeostasis. Many bone disorders such as osteo porosis and osteopetrosis are associated with a deregulation of the balance
CONTENTS
3.1 Introduction ..........................................................................................................................46 3.2 State of the Art of Mathematical Models of Bone Remodeling ..................................... 49
3.2.1 Cellular Scale Models .............................................................................................. 49 3.2.2 Tissue-Scale Models of BMU Regulation .............................................................50 3.2.3 Organ-Scale Models ................................................................................................ 52
3.3 Modeling the Spatio-Temporal Structure of Cell Distribution in BMUs ..................... 52 3.3.1 Description of the Model ........................................................................................53
