ABSTRACT
Solid liquid equilibrium (SLE) studies are essential to the industrial areas such as the safe operation of pipe lines and the design of crystallizers. The solubility of a solid in a liquid solvent is determined from a knowledge of the heat of fusion (ΔHm), melting point (Tm) and the activity coefficient, γ
∞ at any temperature, T (in K). Of the several methods of estimating γ∞(such as Wilson and NRTL models), the UNIFAC model based on group contributions is the most commonly used. However, the approaches used in the calculation of solubilities such as molecular dynamic simulations, equations of state and UNIFAC, although provide reasonable estimates for individual binary mixtures, are too complicated for the development of a generalized method, using larger SLE data bases. Our present work is a step in this direction.
