ABSTRACT
ABSTRACT: Objective: Evaluate the eect of 1 × ED95 or two times of vecuronium bromide used for anesthesia induction on the thyroid operation intraoperative recurrent laryngeal nerve monitoring. Methods: Select 117 cases of thyroid operation patients, male or female, aged 23-67 years old, with a weight of 52-84 kg. The ASA classification is level I or II. Adopt the method of the table of random numbers, and randomly divide them into three groups: Group I (n = 39), Group II (n = 40), Group III (n = 38). Intravenously inject midazolam 2 mg, propofol 2 mg/kg, and sufentanil 0.5 ug/kg in turn. After the eyelash reflex disappears, intravenously inject vecuronium bromide 0.05 mg/kg to Group I and vecuronium bromide 0.1 mg/kg to Group II. After 5 minutes, insert recurrent laryngeal nerve monitoring special tracheal tube; Group III inhales sevoflurane, and recurrent laryngeal nerve monitoring special tracheal tube is inserted when the end-tidal concentration achieves 4%. After the endotracheal intubation, make the mechanical ventilation, inhaling sevoflurane-nitrous oxide-oxygen to maintain the anesthesia. Record the endotracheal intubation condition scores of each group. Adopt nerve electromyography monitor to monitor recurrent laryngeal nerve-evoked myogenic potential. When the operation continues to the 30-minute time point, record the amplitude of the evoked myogenic potential every 5 minutes until the operation continues to the 70-minute time point; monitor SBP, DBP, and HR during the experimental process. Results: During the experimental process, SBP, DBP, and HR are all maintained in the normal ranges. The one-time success rates of endotracheal intubation of the three groups are all 100%, but compared with Group III the endotracheal intubation condition evaluations of Groups I and II are higher (P < .05); Groups I and III all get eective nerve electromyogram signals at each time point, and compared with Group III the nerve electromyogram signals of Group I decrease at each time point (P < .05), but the electromyogram signals can meet the monitoring demands. The patients of Group II lose signal at the 30-minute time point, and the recurrent laryngeal nerve-evoked electromyogram signals at the 35-, 40-, and 45-minute time points cannot meet the monitoring demands. Conclusion: 1 × ED95 vecuronium bromide used for the anesthesia induction of thyroid operation patients not only does not only provide satisfactory endotracheal intubation condition but also does not influence intraoperative recurrent laryngeal nerve monitoring.
