ABSTRACT
ABSTRACT: A simple and high-efficiency method was developed for the Packed Fiber SolidPhase Extraction (PFSPE) of monoamine neurotransmitters in human plasma using composite nanofibers composing of polyvinyl pyrrolidone and polystyrene as sorbent. The plasma samples without protein precipitation and derivatization were loaded on the PFSPE column and the analytes were eluted from the solid-phase with sulfuric acid-methanol mixture (1:9, V/V) before separation and fluorescent detection by HPLC. The extraction recovery of the composite nanofibers was between 60.3% ~ 72.5%.
